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Articles (36)
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A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection

Cao, Pengxing, Klonis, Nectarios, Zaloumis, Sophie, Khoury, David S., Cromer, Deborah, Davenport, Miles P., Tilley, Leann, Simpson, Julie A., McCaw, James M.

Journal:

Journal of Theoretical Biology

Année:

2017

Langue:

english

Fichier:

PDF, 1.71 MB

english, 2017

Synthesis of a Far Red Absorbing Thiobarbituric Acid Oxonol Derivative as a Fluorescent Probe for Biological Applications

Leslie W. Deady, Andrew B. Hughes, Nectarios Klonis, Nurul H. Quazi, Leann M. Tilley

Journal:

ChemInform

Année:

2004

Fichier:

PDF, 69 KB

2004

A phosphatidylcholine-BODIPY 581/591 conjugate allows mapping of oxidative stress in P. falciparum-infected erythrocytes

Ying Fu, Nectarios Klonis, Cacang Suarna, Ghassan J. Maghzal, Roland Stocker, Leann Tilley

Journal:

Cytometry Part A

Année:

2009

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2009

Dual labeling with a far red probe permits analysis of growth and oxidative stress in P. falciparum-infected erythrocytes

Ying Fu, Leann Tilley, Shannon Kenny, Nectarios Klonis

Journal:

Cytometry Part A

Année:

2010

Langue:

english

Fichier:

PDF, 680 KB

english, 2010

Characterization of a series of far-red-absorbing thiobarbituric acid oxonol derivatives as fluorescent probes for biological applications

Nectarios Klonis, Nurul H. Quazi, Les W. Deady, Andrew B. Hughes, Leann Tilley

Journal:

Analytical Biochemistry

Année:

2003

Langue:

english

Fichier:

PDF, 244 KB

english, 2003

Spectral properties of the prototropic forms of fluorescein in aqueous solution

Nectarios Klonis, William H. Sawyer

Journal:

Journal of Fluorescence

Année:

1996

Langue:

english

Fichier:

PDF, 963 KB

english, 1996

Fluorescence photobleaching analysis for the study of cellular dynamics

Nectarios Klonis, Melanie Rug, Ian Harper, Mark Wickham, Alan Cowman, Leann Tilley

Journal:

European Biophysics Journal

Année:

2002

Langue:

english

Fichier:

PDF, 246 KB

english, 2002

Dual-channel photobleaching FRET microscopy for improved resolution of protein association states in living cells

Andrew H. A. Clayton, Nectarios Klonis, Stephen H. Cody, Edouard C. Nice

Journal:

European Biophysics Journal

Année:

2005

Langue:

english

Fichier:

PDF, 351 KB

english, 2005

Solution behavior of hematin under acidic conditions and implications for its interactions with chloroquine

Maria P. Crespo, Leann Tilley, Nectarios Klonis

Journal:

JBIC Journal of Biological Inorganic Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 541 KB

english, 2010

Food vacuole-associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum

Katherine E. Jackson, Nectarios Klonis, David J. P. Ferguson, Akinola Adisa, Con Dogovski, Leann Tilley

Journal:

Molecular Microbiology

Année:

2004

Langue:

english

Fichier:

PDF, 659 KB

english, 2004

Trafficking determinants for PfEMP3 export and assembly under the Plasmodium falciparum-infected red blood cell membrane

Ellen Knuepfer, Melanie Rug, Nectarios Klonis, Leann Tilley, Alan F. Cowman

Journal:

Molecular Microbiology

Année:

2005

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2005

Trafficking determinants for PfEMP3 export and assembly under the Plasmodium falciparum-infected red blood cell membrane

Ellen Knuepfer, Melanie Rug, Nectarios Klonis, Leann Tilley, Alan F. Cowman

Journal:

Molecular Microbiology

Année:

2006

Langue:

english

Fichier:

PDF, 126 KB

english, 2006

Electron tomography of the Maurer's cleft organelles of Plasmodium falciparum-infected erythrocytes reveals novel structural features

Eric Hanssen, Rachid Sougrat, Sarah Frankland, Samantha Deed, Nectarios Klonis, Jennifer Lippincott-Schwartz, Leann Tilley

Journal:

Molecular Microbiology

Année:

2008

Langue:

english

Fichier:

PDF, 905 KB

english, 2008

Spectral Properties of Fluorescein in Solvent-Water Mixtures: Applications as a Probe of Hydrogen Bonding Environments in Biological Systems

Nectarios Klonis, Andrew H. A. Clayton, Edward W. Voss Jr., William H. Sawyer

Journal:

Photochemistry and Photobiology

Année:

1998

Langue:

english

Fichier:

PDF, 1.13 MB

english, 1998

Characterization of a Series of Far Red Absorbing Perylene Diones: A New Class of Fluorescent Probes for Biological Applications

Nectarios Klonis, Huiqin Wang, Nurul H. Quazi, Joanne L. Casey, Gregory M. Neumann, Dean R. Hewish, Andrew B. Hughes, Les W. Deady, Leann Tilley

Journal:

Journal of Fluorescence

Année:

2001

Langue:

english

Fichier:

PDF, 929 KB

english, 2001

Effect of Solvent–Water Mixtures on the Prototropic Equilibria of Fluorescein and on the Spectral Properties of the Monoanion

Nectarios Klonis, William H. Sawyer

Journal:

Photochemistry and Photobiology

Année:

2000

Langue:

english

Fichier:

PDF, 93 KB

english, 2000

The Thiourea Group Modulates the Fluorescence Emission Decay of Fluorescein-labeled Molecules

Nectarios Klonis, William H. Sawyer

Journal:

Photochemistry and Photobiology

Année:

2003

Langue:

english

Fichier:

PDF, 157 KB

english, 2003

Synergistic interaction of a chloroquine metabolite with chloroquine against drug-resistant malaria parasites

Martha Kalkanidis, Nectarios Klonis, Serena Tschan, Leslie W Deady, Leann Tilley

Journal:

Biochemical Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 326 KB

english, 2004

Re-assessing the locations of components of the classical vesicle-mediated trafficking machinery in transfected Plasmodium falciparum

Akinola Adisa, Sarah Frankland, Melanie Rug, Katherine Jackson, Alexander G. Maier, Peter Walsh, Trevor Lithgow, Nectarios Klonis, Paul R. Gilson, Alan F. Cowman, Leann Tilley

Journal:

International Journal for Parasitology

Année:

2007

Langue:

english

Fichier:

PDF, 2.23 MB

english, 2007

Whole cell imaging reveals novel modular features of the exomembrane system of the malaria parasite, Plasmodium falciparum

Eric Hanssen, Peter Carlton, Samantha Deed, Nectarios Klonis, John Sedat, Joe DeRisi, Leann Tilley

Journal:

International Journal for Parasitology

Année:

2010

Langue:

english

Fichier:

PDF, 746 KB

english, 2010

The astrocytic response in early experimental autoimmune encephalomyelitis occurs across both the grey and white matter compartments

Hong Pham, Anton A. Ramp, Nectarios Klonis, Sze Woei Ng, Armelle Klopstein, Margaret M. Ayers, Jacqueline M. Orian

Journal:

Journal of Neuroimmunology

Année:

2009

Langue:

english

Fichier:

PDF, 1.83 MB

english, 2009

Illuminating Plasmodium falciparum-infected red blood cells

Leann Tilley, Geoff McFadden, Alan Cowman, Nectarios Klonis

Journal:

Trends in Parasitology

Année:

2007

Langue:

english

Fichier:

PDF, 1.52 MB

english, 2007

Novel phenothiazine antimalarials: synthesis, antimalarial activity, and inhibition of the formation of β-haematin

Martha Kalkanidis, Nectarios Klonis, Leann Tilley, Leslie W Deady

Journal:

Biochemical Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 198 KB

english, 2002

Cryo transmission X-ray imaging of the malaria parasite, P. falciparum

Eric Hanssen, Christian Knoechel, Nectarios Klonis, Nurhidanatasha Abu-Bakar, Samantha Deed, Mark LeGros, Carolyn Larabell, Leann Tilley

Journal:

Journal of Structural Biology

Année:

2011

Langue:

english

Fichier:

PDF, 900 KB

english, 2011

Hematin−Hematin Self-Association States Involved in the Formation and Reactivity of the Malaria Parasite Pigment, Hemozoin

Klonis, Nectarios, Dilanian, Ruben, Hanssen, Eric, Darmanin, Connie, Streltsov, Victor, Deed, Samantha, Quiney, Harry, Tilley, Leann

Journal:

Biochemistry

Année:

2010

Langue:

english

Fichier:

PDF, 3.52 MB

english, 2010

Novel Conjugated Quinoline–Indoles Compromise Plasmodium falciparum Mitochondrial Function and Show Promising Antimalarial Activity

Teguh, Silvia C., Klonis, Nectarios, Duffy, Sandra, Lucantoni, Leonardo, Avery, Vicky M., Hutton, Craig A., Baell, Jonathan B., Tilley, Leann

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2013

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

Klonis, Nectarios, Creek, Darren J, Tilley, Leann

Journal:

Current Opinion in Microbiology

Année:

2013

Langue:

english

Fichier:

PDF, 630 KB

english, 2013

Novel Endoperoxide Antimalarials: Synthesis, Heme Binding, and Antimalarial Activity

Taylor, Dennis K., Avery, Thomas D., Greatrex, Ben W., Tiekink, Edward R. T., Macreadie, Ian G., Macreadie, Peter I., Humphries, Adam D., Kalkanidis, Martha, Fox, Emma N., Klonis, Nectarios, Tilley, L

Journal:

Journal of Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 122 KB

english, 2004

Optimal assay design for determining the in vitro sensitivity of ring stage Plasmodium falciparum to artemisinins

Xie, Stanley C., Dogovski, Con, Kenny, Shannon, Tilley, Leann, Klonis, Nectarios

Journal:

International Journal for Parasitology

Année:

2014

Langue:

english

Fichier:

PDF, 826 KB

english, 2014

Synthesis of a Far Red Absorbing Thiobarbituric Acid Oxonol Derivative as a Fluorescent Probe for Biological Applications

Deady, Leslie W., Hughes, Andrew B., Klonis, Nectarios, Quazi, Nurul H., Tilley, Leann M.

Journal:

Synthetic Communications

Année:

2003

Langue:

english

Fichier:

PDF, 213 KB

english, 2003

Effect of Solvent–Water Mixtures on the Prototropic Equilibria of Fluorescein and on the Spectral Properties of the Monoanion¶

Klonis, Nectarios, Sawyer, William H.

Journal:

Photochemistry and Photobiology

Année:

2000

Langue:

english

Fichier:

PDF, 103 KB

english, 2000

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

Nectarios Klonis, Maria P. Crespo-Ortiz, Iveta Bottova, Nurhidanatasha Abu-Bakar, Shannon Kenny, Philip J. Rosenthal and Leann Tilley

Journal:

Proceedings of the National Academy of Sciences

Année:

2011

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2011

Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages

Dearnley, Megan, Chu, Trang, Zhang, Yao, Looker, Oliver, Huang, Changjin, Klonis, Nectarios, Yeoman, Jeff, Kenny, Shannon, Arora, Mohit, Osborne, James M., Chandramohanadas, Rajesh, Zhang, Sulin, Dixo

Journal:

Proceedings of the National Academy of Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 1.19 MB

english, 2016

A comparison of the exposure time-dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wildtype and mutant Plasmodium falciparum

Yang, Tuo, Xie, Stanley C., Cao, Pengxing, Giannangelo, Carlo, McCaw, James, Creek, Darren J., Charman, Susan A., Klonis, Nectarios, Tilley, Leann

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2016

Langue:

english

Fichier:

PDF, 1.67 MB

english, 2016

Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum

Klonis, Nectarios, Tan, Olivia, Jackson, Katherine, Goldberg, Daniel, Klemba, Michael, Tilley, Leann

Journal:

Biochemical Journal

Année:

2007

Langue:

english

Fichier:

PDF, 678 KB

english, 2007

A dynamic stress model explains the delayed drug effect in artemisinin treatment of Plasmodium falciparum

Cao, Pengxing, Klonis, Nectarios, Zaloumis, Sophie, Dogovski, Con, Xie, Stanley C., Saralamba, Sompob, White, Lisa J., Fowkes, Freya J. I., Tilley, Leann, Simpson, Julie A., McCaw, James M.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2017

Langue:

english

Fichier:

PDF, 7.12 MB

english, 2017